MTiness in pseudo-malignant behavior of trophoblasts during embryo implantation

Abortive Embryo Implantation and Trophoblasts during Successful and Endometrium, Endometrial Lymphocytes, Differential Gene Expression in

Differential gene expression in endometrium, endometrial lymphocytes, and trophoblasts during successful and abortive embryo implantation.

Prenatal mortality reaching 30% occurs during the first weeks of gestation in commercial swine. Mechanisms for this are unknown although poor uterine blood supply has been postulated. In other species, vascular endothelial growth factor, hypoxia-inducible factor 1-alpha, and IFN-gamma regulate gestational endometrial angiogenesis. Vascular endothelial growth factor and hypoxia-inducible factor ...

The cytokine network during embryo implantation.

Embryo implantation is an essential step in mammalian pregnancy. The molecular events of embryonic attachment to the endometrial epithelium and the subsequent invasion of the stroma have long been of interest. The process involves both the scientific interest of reproductive biologists and clinical interest of physicians that care for infertility couples. Understanding the molecular factors inv...

Characterization of calreticulin expression in mouse endometrium during embryo implantation.

Calreticulin (CRT), a Ca(2+)-binding storage protein and chaperone in the endoplasmic reticulum, modulates cell adhesiveness and integrin-dependent Ca(2+) signaling. However, the role of CRT during implantation remains poorly understood. In the present study, we characterized the expression of CRT mRNA and the protein in mouse endometria from pregnancy DI to D7. Real-Time PCR and in situ hybrid...

Hysteroscopic Subendometrial Embryo Delivery (SEED), Mechanical Embryo Implantation

Background A major hurdle to improved in vitro fertilization (IVF) success rate is defective endometrial receptivity and implantation. Various techniques have been advocated to increase implantation while reducing side effects. Currently, embryo transfer (ET) is performed blindly without direct visualization. As such, we sought to develop a technique utilizing a flexible minihysteroscope with a...